What it is: Paroxetine is a non-hormonal prescription selective serotonin reuptake inhibitor (SSRI) that, at low doses, is prescribed to treat hot flashes and night sweats. Paroxetine works by modulating your brain’s serotonin levels, which are believed to play a role in temperature regulation. Paroxetine is a potential non-hormonal alternative treatment for your hot flashes and night sweats.
Brisdelle, a brand name of paroxetine, is FDA-approved at 7.5 mg to treat hot flashes and night sweats. Paroxetine, at 10 mg, is also prescribed off-label to treat these symptoms.
How it works: Taken orally at night, paroxetine blocks the reuptake of serotonin in the brain, making more serotonin available. This process is how paroxetine is believed to improve your body’s ability to regulate its temperature and potentially reduce hot flashes and night sweats.
What the research says: A 2015 study found that paroxetine effectively reduced the frequency of hot flashes and night sweats in women by up to 67%. Another 2015 study found that paroxetine reduced nighttime awakenings due to hot flashes and night sweats and increased sleep duration when taken at 7.5 mg.
Brand name: Brisdelle; Evernow uses the generic paroxetine
Range of dosage: 10 mg orally/day
Safety information: If you have taken a monoamine oxidase inhibitor (MAOI), are being treated for depression or bipolar disorder or are taking tamoxifen, paroxetine may not be for you. You should speak to your in-person care provider to determine your best treatment options. To learn more about the risks and benefits of paroxetine and to read the boxed warning, see this Brisdelle safety information.